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Friday, October 1st



Central Europe Summer Time (CEST)

Jesús F. San-Miguel, Heinz Ludwig
Moderator: Heinz Ludwig
09:10 - 09:30Genomics in myeloma: pathogenic and clinical implications
Jill Corre
09:30 - 09:50How important are epigenetics in MM
Felipe Prósper
09:50 - 10:10Druggable myeloma therapeutics. Pathogenetic pathways
Enrique Ocio
10:10 - 10:25Experts' discussion around 5 burning questions:
1. What techniques? Clinical meaning of mutations
2. The number of genetics lesions and percentage of abnormal cells matter for clinical decisions?
3. What is the meaning of genetic changes in MGUS and SMM?
4. Clinical future for epigenetics
5. What are the most relevant pathways and drugs in myeloma?
Discussants: Jill Corre, Felipe Prósper, Enrique Ocio, Pieter Sonneveld
Moderator: Heinz Ludwig
10:35 - 10:55MRD
Bruno Paiva
10:55 - 11:15Mass spectrometry
Noemí Puig
11:15 - 11:35MRI and CT-PET
Elena Zamagni
11:35 - 11:50Experts' discussion around 5 burning topics:
1. New response criteria
2. Optimal MRD technique
3. Prognostic factors or biomarker for treatment
4. Should we stratify patients?
5. Should we implement PET in routine clinical practice?
Discussants: Bruno Paiva, Noemí Puig, Elena Zamagni, Jill Corre
Moderator: Jesús F. San-Miguel
12:00 - 12:201. Difficult to treat MM (extramedullary, CNS, oligosecretory, solitary, PCL, biochemical relapse)
Kwee Yong
12:20 - 12:402. MGUS with systemic manifestations
Joan Bladé
12:40 - 13:003. Emergencies and supportive care (cord compression, RI, hyperCa, bone disease)
Evangelos Terpos
13:00 - 13:15Questions & discussion
Moderator: Jesús F. San-Miguel
14:00 - 14:20Infections and myeloma
Heinz Ludwig
14:20 - 14:30Questions & discussion
Moderator: Jesús F. San-Miguel
14:40 - 15:00Smoldering MM
M. Victoria Mateos
15:00 - 15:20Induction and transplant
Philippe Moreau
15:20 - 15:40Consolidation and maintenance
Pieter Sonneveld
15:40 - 15:55Experts' discussion on 7 burning topics:
1. How to define high risk SMM
2. To treat or not to treat SMM
3. Best induction
4. Early vs. late transplant
5. One vs. two
6. Consolidation & maintenance
7. High risk
Discussants: M. Victoria Mateos, Philippe Moreau, Pieter Sonneveld, Joan Bladé
Moderator: Heinz Ludwig
16:05 - 16:25How I treat elderly patients
Thierry Facon
16:25 - 16:40Experts' discussion on 5 burning topics:
1. Optimal combination and duration
2. Maintenance/ continuous
3. Do we need alkylators?
4. High risk
5. Frailty
Discussants: Thierry Facon, M. Victoria Mateos, Enrique Ocio, Kwee Yong

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